SMARCC2
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | MIM:601734 | Ensembl:ENSG00000139613 | HGNC:HGNC:11105 | PA35955 | 12q13.2 |
GO terms in SMARCC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | HDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | HDA | GO:0031492 | nucleosomal DNA binding |
| BP | IDA | GO:0006337 | nucleosome disassembly |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007399 | nervous system development |
| BP | HDA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| CC | HDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016514 | SWI/SNF complex |
| CC | IPI | GO:0017053 | transcriptional repressor complex |
| CC | HDA | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0071564 | npBAF complex |
| CC | ISS | GO:0071565 | nBAF complex |
Gene expression in normal tissue: SMARCC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMARCC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| biocarta | hswisnfpathway | chromatin remodeling by hswi/snf atp-dependent complexes |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMARCC2
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