Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2MIM:601734Ensembl:ENSG00000139613HGNC:HGNC:11105PA3595512q13.2

GO terms in SMARCC2

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFHDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFHDAGO:0031492nucleosomal DNA binding
BPIDAGO:0006337nucleosome disassembly
BPIDAGO:0006338chromatin remodeling
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007399nervous system development
BPHDAGO:0043044ATP-dependent chromatin remodeling
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
CCHDAGO:0000790nuclear chromatin
CCIDAGO:0016514SWI/SNF complex
CCIPIGO:0017053transcriptional repressor complex
CCHDAGO:0032991protein-containing complex
CCISSGO:0071564npBAF complex
CCISSGO:0071565nBAF complex

Gene expression in normal tissue: SMARCC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMARCC2

DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214858RMTs methylate histone arginines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
biocartahswisnfpathwaychromatin remodeling by hswi/snf atp-dependent complexes
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP4204Tumor suppressor activity of SMARCB1

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMARCC2