SNRPB
Summary: The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| small nuclear ribonucleoprotein polypeptides B and B1 | MIM:182282 | Ensembl:ENSG00000125835 | HGNC:HGNC:11153 | PA35995 | 20p13 |
GO terms in SNRPB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030620 | U2 snRNA binding |
| MF | IPI | GO:0070034 | telomerase RNA binding |
| MF | IEA | GO:0071208 | histone pre-mRNA DCP binding |
| BP | IDA | GO:0000387 | spliceosomal snRNP assembly |
| BP | TAS | GO:0000387 | spliceosomal snRNP assembly |
| BP | IBA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IC | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0006369 | termination of RNA polymerase II transcription |
| BP | IDA | GO:0006479 | protein methylation |
| BP | TAS | GO:0008334 | histone mRNA metabolic process |
| BP | TAS | GO:0008380 | RNA splicing |
| BP | TAS | GO:0051170 | import into nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005681 | spliceosomal complex |
| CC | IBA | GO:0005682 | U5 snRNP |
| CC | IDA | GO:0005683 | U7 snRNP |
| CC | IBA | GO:0005685 | U1 snRNP |
| CC | IDA | GO:0005685 | U1 snRNP |
| CC | IBA | GO:0005686 | U2 snRNP |
| CC | IBA | GO:0005687 | U4 snRNP |
| CC | IDA | GO:0005687 | U4 snRNP |
| CC | IDA | GO:0005689 | U12-type spliceosomal complex |
| CC | IDA | GO:0005697 | telomerase holoenzyme complex |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0030532 | small nuclear ribonucleoprotein complex |
| CC | IDA | GO:0034709 | methylosome |
| CC | IDA | GO:0034719 | SMN-Sm protein complex |
| CC | IBA | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| CC | IBA | GO:0071004 | U2-type prespliceosome |
| CC | IDA | GO:0071005 | U2-type precatalytic spliceosome |
| CC | IDA | GO:0071007 | U2-type catalytic step 2 spliceosome |
| CC | IBA | GO:0071013 | catalytic step 2 spliceosome |
| CC | IDA | GO:0071013 | catalytic step 2 spliceosome |
| CC | IEA | GO:0071204 | histone pre-mRNA 3'end processing complex |
Gene expression in normal tissue: SNRPB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SNRPB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-109688 | Cleavage of Growing Transcript in the Termination Region |
| reactome | R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs |
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72165 | mRNA Splicing - Minor Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-73856 | RNA Polymerase II Transcription Termination |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75067 | Processing of Capped Intronless Pre-mRNA |
| reactome | R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SNRPB
CLASSFICATION
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