Summary: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

suppressor of cytokine signaling 4MIM:616337Ensembl:ENSG00000180008HGNC:HGNC:19392PA16474247714q22.3

Gene Categories:


GO terms in SOCS4

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0007175negative regulation of epidermal growth factor-activated receptor activity
BPIEAGO:0016567protein ubiquitination
BPIEAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIEAGO:0035556intracellular signal transduction
BPIEAGO:0040008regulation of growth
MFIPIGO:0005515protein binding

Gene expression in normal tissue: SOCS4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOCS4

DatabasePathway IDPathway Des.
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
wikipathwaysWP1584Type II diabetes mellitus
wikipathwaysWP4105Transcriptional regulation by RUNX1
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939242RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOCS4