SORT1


Summary: This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sortilin 1MIM:602458Ensembl:ENSG00000134243HGNC:HGNC:11186PA360231p13.3|1p21.3-p13.1

Gene Categories:

CELL SURFACE

GO terms in SORT1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0010465nerve growth factor receptor activity
MFIPIGO:0019899enzyme binding
MFIDAGO:0030379neurotensin receptor activity, non-G-protein coupled
MFIPIGO:0048406nerve growth factor binding
CCIEAGO:0005765lysosomal membrane
CCIDAGO:0005769early endosome
CCIEAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCNASGO:0005886plasma membrane
CCIDAGO:0005905clathrin-coated pit
CCIDAGO:0009986cell surface
CCIEAGO:0010008endosome membrane
CCIDAGO:0016021integral component of membrane
CCIDAGO:0030136clathrin-coated vesicle
CCIEAGO:0030140trans-Golgi network transport vesicle
CCIEAGO:0030425dendrite
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIDAGO:0031410cytoplasmic vesicle
CCIEAGO:0031965nuclear membrane
CCIEAGO:0032580Golgi cisterna membrane
CCIEAGO:0043025neuronal cell body
CCIDAGO:0048471perinuclear region of cytoplasm
BPIEAGO:0001503ossification
BPIDAGO:0006895Golgi to endosome transport
BPIDAGO:0006897endocytosis
BPIMPGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007218neuropeptide signaling pathway
BPIEAGO:0007275multicellular organism development
BPIDAGO:0008333endosome to lysosome transport
BPIDAGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIMPGO:0010468regulation of gene expression
BPIMPGO:0014902myotube differentiation
BPIDAGO:0016050vesicle organization
BPIDAGO:0032509endosome transport via multivesicular body sorting pathway
BPIMPGO:0032868response to insulin
BPIEAGO:0038180nerve growth factor signaling pathway
BPIEAGO:0045599negative regulation of fat cell differentiation
BPIMPGO:0046323glucose import
BPIMPGO:0048011neurotrophin TRK receptor signaling pathway
BPIDAGO:0048227plasma membrane to endosome transport
BPIDAGO:0051005negative regulation of lipoprotein lipase activity
BPIEAGO:1904037positive regulation of epithelial cell apoptotic process

Gene expression in normal tissue: SORT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SORT1


DatabasePathway IDPathway Des.
netpathPathway_BDNFBDNF
pidp75ntrpathwayp75(NTR)-mediated signaling
kegghsa04142Lysosome - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04979Cholesterol metabolism - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SORT1

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