SOX1


Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SRY-box 1MIM:602148Ensembl:ENSG00000182968HGNC:HGNC:11189PA3602613q34

GO terms in SOX1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001764neuron migration
BPIEAGO:0002089lens morphogenesis in camera-type eye
BPNASGO:0006325chromatin organization
BPIBAGO:0006355regulation of transcription, DNA-templated
BPNASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIBAGO:0007417central nervous system development
BPIBAGO:0009653anatomical structure morphogenesis
BPIEAGO:0021521ventral spinal cord interneuron specification
BPIEAGO:0021884forebrain neuron development
BPIBAGO:0030154cell differentiation
BPIBAGO:0030182neuron differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:1990830cellular response to leukemia inhibitory factor
CCIBAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIBAGO:0044798nuclear transcription factor complex
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFNASGO:0003677DNA binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: SOX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOX1


DatabasePathway IDPathway Des.
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP363Wnt Signaling Pathway
netpathPathway_WntWnt

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX1

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