SP8
Summary: The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Sp8 transcription factor | MIM:608306 | Ensembl:ENSG00000164651 | HGNC:HGNC:19196 | PA134893390 | 7p21.1 |
GO terms in SP8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005634 | nucleus |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0009953 | dorsal/ventral pattern formation |
| BP | IEA | GO:0009954 | proximal/distal pattern formation |
| BP | IEA | GO:0030326 | embryonic limb morphogenesis |
Gene expression in normal tissue: SP8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SP8
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SP8
CLASSFICATION
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