SPHK1
Summary: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
sphingosine kinase 1 | MIM:603730 | Ensembl:ENSG00000176170 | HGNC:HGNC:11240 | PA36070 | 17q25.1 |
GO terms in SPHK1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0000287 | magnesium ion binding |
MF | ISS | GO:0000287 | magnesium ion binding |
MF | IDA | GO:0003677 | DNA binding |
MF | IEA | GO:0003951 | NAD+ kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0005516 | calmodulin binding |
MF | IDA | GO:0005524 | ATP binding |
MF | IDA | GO:0008481 | sphinganine kinase activity |
MF | TAS | GO:0008481 | sphinganine kinase activity |
MF | IDA | GO:0017050 | D-erythro-sphingosine kinase activity |
MF | TAS | GO:0017050 | D-erythro-sphingosine kinase activity |
MF | IMP | GO:0038036 | sphingosine-1-phosphate receptor activity |
MF | IPI | GO:0051721 | protein phosphatase 2A binding |
CC | IEA | GO:0005634 | nucleus |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
BP | IEA | GO:0001568 | blood vessel development |
BP | IEA | GO:0003376 | sphingosine-1-phosphate signaling pathway |
BP | TAS | GO:0006457 | protein folding |
BP | IDA | GO:0006670 | sphingosine metabolic process |
BP | IEA | GO:0006954 | inflammatory response |
BP | TAS | GO:0007165 | signal transduction |
BP | IEA | GO:0007420 | brain development |
BP | IMP | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
BP | IDA | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
BP | IDA | GO:0019722 | calcium-mediated signaling |
BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
BP | IDA | GO:0030307 | positive regulation of cell growth |
BP | IDA | GO:0030335 | positive regulation of cell migration |
BP | IDA | GO:0031398 | positive regulation of protein ubiquitination |
BP | IEA | GO:0032651 | regulation of interleukin-1 beta production |
BP | TAS | GO:0035556 | intracellular signal transduction |
BP | IDA | GO:0043066 | negative regulation of apoptotic process |
BP | TAS | GO:0043066 | negative regulation of apoptotic process |
BP | IDA | GO:0045766 | positive regulation of angiogenesis |
BP | IDA | GO:0045931 | positive regulation of mitotic cell cycle |
BP | IDA | GO:0045987 | positive regulation of smooth muscle contraction |
BP | IGI | GO:0046512 | sphingosine biosynthetic process |
BP | IMP | GO:0046512 | sphingosine biosynthetic process |
BP | NAS | GO:0046521 | sphingoid catabolic process |
BP | IEA | GO:0046834 | lipid phosphorylation |
BP | IDA | GO:0048146 | positive regulation of fibroblast proliferation |
BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
BP | IMP | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
Gene expression in normal tissue: SPHK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPHK1
Database | Pathway ID | Pathway Des. |
---|---|---|
netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
pid | integrin3_pathway | Beta3 integrin cell surface interactions |
pid | pdgfrbpathway | PDGFR-beta signaling pathway |
pid | s1p_meta_pathway | Sphingosine 1-phosphate (S1P) pathway |
pid | s1p_s1p1_pathway | S1P1 pathway |
kegg | hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
humancyc | PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
wikipathways | WP1422 | Sphingolipid Metabolism |
wikipathways | WP26 | Signal Transduction of S1P Receptor |
wikipathways | WP4142 | Metabolism of Spingolipids in ER and Golgi apparatus |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
reactome | R-HSA-194138 | Signaling by VEGF |
reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
reactome | R-HSA-391251 | Protein folding |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-428157 | Sphingolipid metabolism |
reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
reactome | R-HSA-556833 | Metabolism of lipids |
reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
biocarta | edg1pathway | phospholipids as signalling intermediaries |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD309 | 17AAG | 2 |
iGMDRD68 | Paclitaxel | 2 |
iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPHK1