SPHK1


Summary: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sphingosine kinase 1MIM:603730Ensembl:ENSG00000176170HGNC:HGNC:11240PA3607017q25.1

GO terms in SPHK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFISSGO:0000287magnesium ion binding
MFIDAGO:0003677DNA binding
MFIEAGO:0003951NAD+ kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005516calmodulin binding
MFIDAGO:0005524ATP binding
MFIDAGO:0008481sphinganine kinase activity
MFTASGO:0008481sphinganine kinase activity
MFIDAGO:0017050D-erythro-sphingosine kinase activity
MFTASGO:0017050D-erythro-sphingosine kinase activity
MFIMPGO:0038036sphingosine-1-phosphate receptor activity
MFIPIGO:0051721protein phosphatase 2A binding
CCIEAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
BPIEAGO:0001568blood vessel development
BPIEAGO:0003376sphingosine-1-phosphate signaling pathway
BPTASGO:0006457protein folding
BPIDAGO:0006670sphingosine metabolic process
BPIEAGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPIEAGO:0007420brain development
BPIMPGO:0010800positive regulation of peptidyl-threonine phosphorylation
BPIDAGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIDAGO:0019722calcium-mediated signaling
BPTASGO:0030148sphingolipid biosynthetic process
BPIDAGO:0030307positive regulation of cell growth
BPIDAGO:0030335positive regulation of cell migration
BPIDAGO:0031398positive regulation of protein ubiquitination
BPIEAGO:0032651regulation of interleukin-1 beta production
BPTASGO:0035556intracellular signal transduction
BPIDAGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIDAGO:0045766positive regulation of angiogenesis
BPIDAGO:0045931positive regulation of mitotic cell cycle
BPIDAGO:0045987positive regulation of smooth muscle contraction
BPIGIGO:0046512sphingosine biosynthetic process
BPIMPGO:0046512sphingosine biosynthetic process
BPNASGO:0046521sphingoid catabolic process
BPIEAGO:0046834lipid phosphorylation
BPIDAGO:0048146positive regulation of fibroblast proliferation
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:1901224positive regulation of NIK/NF-kappaB signaling

Gene expression in normal tissue: SPHK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPHK1


DatabasePathway IDPathway Des.
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidpdgfrbpathwayPDGFR-beta signaling pathway
pids1p_meta_pathwaySphingosine 1-phosphate (S1P) pathway
pids1p_s1p1_pathwayS1P1 pathway
kegghsa00600Sphingolipid metabolism - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
humancycPWY3DJ-11470sphingosine and sphingosine-1-phosphate metabolism
wikipathwaysWP1422Sphingolipid Metabolism
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP4142Metabolism of Spingolipids in ER and Golgi apparatus
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesis
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartaedg1pathwayphospholipids as signalling intermediaries

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2
iGMDRD68Paclitaxel2
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPHK1

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