SPIB
Summary: The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Spi-B transcription factor | MIM:606802 | Ensembl:ENSG00000269404 | HGNC:HGNC:11242 | PA36072 | 19q13.33 |
GO terms in SPIB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IMP | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005737 | cytoplasm |
Gene expression in normal tissue: SPIB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPIB
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPIB
CLASSFICATION
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