SPRED1
Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sprouty related EVH1 domain containing 1 | MIM:609291 | Ensembl:ENSG00000166068 | HGNC:HGNC:20249 | PA134897382 | 15q14 |
GO terms in SPRED1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0005173 | stem cell factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0019902 | phosphatase binding |
| MF | ISS | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005901 | caveola |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0000188 | inactivation of MAPK activity |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IMP | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| BP | IDA | GO:0010923 | negative regulation of phosphatase activity |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | TAS | GO:0043408 | regulation of MAPK cascade |
| BP | IMP | GO:0043409 | negative regulation of MAPK cascade |
| BP | ISS | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator |
| BP | IMP | GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | ISS | GO:0090311 | regulation of protein deacetylation |
Gene expression in normal tissue: SPRED1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPRED1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5658442 | Regulation of RAS by GAPs |
| reactome | R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| netpath | Pathway_KitReceptor | KitReceptor |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPRED1
CLASSFICATION
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