SPRY4


Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sprouty RTK signaling antagonist 4MIM:607984Ensembl:ENSG00000187678HGNC:HGNC:15533PA379755q31.3

GO terms in SPRY4


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIEAGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCIEAGO:0032587ruffle membrane
BPIEAGO:0007275multicellular organism development
BPIBAGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPIBAGO:0043407negative regulation of MAP kinase activity
BPIBAGO:0046580negative regulation of Ras protein signal transduction
BPIBAGO:0048513animal organ development
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: SPRY4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPRY4


DatabasePathway IDPathway Des.
biocartasprypathwaysprouty regulation of tyrosine kinase signals
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPRY4

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