SPRY4
Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
sprouty RTK signaling antagonist 4 | MIM:607984 | Ensembl:ENSG00000187678 | HGNC:HGNC:15533 | PA37975 | 5q31.3 |
GO terms in SPRY4
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
CC | IEA | GO:0005737 | cytoplasm |
CC | IBA | GO:0005829 | cytosol |
CC | HDA | GO:0005925 | focal adhesion |
CC | IEA | GO:0032587 | ruffle membrane |
BP | IEA | GO:0007275 | multicellular organism development |
BP | IBA | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
BP | IBA | GO:0043407 | negative regulation of MAP kinase activity |
BP | IBA | GO:0046580 | negative regulation of Ras protein signal transduction |
BP | IBA | GO:0048513 | animal organ development |
BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: SPRY4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPRY4
Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
netpath | Pathway_EGFR1 | EGFR1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPRY4