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SPRY4

Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
sprouty RTK signaling antagonist 4	MIM:607984	Ensembl:ENSG00000187678	HGNC:HGNC:15533	PA37975	5q31.3

GO terms in SPRY4

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
CC	IEA	GO:0005737	cytoplasm
CC	IBA	GO:0005829	cytosol
CC	HDA	GO:0005925	focal adhesion
CC	IEA	GO:0032587	ruffle membrane
BP	IEA	GO:0007275	multicellular organism development
BP	IBA	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
BP	IBA	GO:0043407	negative regulation of MAP kinase activity
BP	IBA	GO:0046580	negative regulation of Ras protein signal transduction
BP	IBA	GO:0048513	animal organ development
BP	IEA	GO:0070373	negative regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: SPRY4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPRY4

Database	Pathway ID	Pathway Des.
biocarta	sprypathway	sprouty regulation of tyrosine kinase signals
netpath	Pathway_EGFR1	EGFR1

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPRY4

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