SRGN
Summary: This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serglycin | MIM:177040 | Ensembl:ENSG00000122862 | HGNC:HGNC:9361 | PA33733 | 10q22.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SRGN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0030141 | secretory granule |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | ISS | GO:0042629 | mast cell granule |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IDA | GO:0008626 | granzyme-mediated apoptotic signaling pathway |
| BP | ISS | GO:0016485 | protein processing |
| BP | IBA | GO:0030502 | negative regulation of bone mineralization |
| BP | IDA | GO:0030502 | negative regulation of bone mineralization |
| BP | IEA | GO:0031214 | biomineral tissue development |
| BP | IBA | GO:0033363 | secretory granule organization |
| BP | ISS | GO:0033364 | mast cell secretory granule organization |
| BP | ISS | GO:0033371 | T cell secretory granule organization |
| BP | ISS | GO:0033373 | maintenance of protease location in mast cell secretory granule |
| BP | ISS | GO:0033382 | maintenance of granzyme B location in T cell secretory granule |
| BP | ISS | GO:0050710 | negative regulation of cytokine secretion |
Gene expression in normal tissue: SRGN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRGN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRGN
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