Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

serine and arginine rich splicing factor 10MIM:605221Ensembl:ENSG00000188529HGNC:HGNC:16713PA284271p36.11

GO terms in SRSF10

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFNASGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFNASGO:0050733RS domain binding
MFNASGO:0051082unfolded protein binding
BPNASGO:0000244spliceosomal tri-snRNP complex assembly
BPIDAGO:0000375RNA splicing, via transesterification reactions
BPIBAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPIBAGO:0000395mRNA 5'-splice site recognition
BPIDAGO:0000398mRNA splicing, via spliceosome
BPNASGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0006376mRNA splice site selection
BPIEAGO:0016482cytosolic transport
BPIBAGO:0045292mRNA cis splicing, via spliceosome
BPIDAGO:0048024regulation of mRNA splicing, via spliceosome
BPIDAGO:0048025negative regulation of mRNA splicing, via spliceosome
CCIBAGO:0016607nuclear speck
CCIDAGO:0016607nuclear speck

Gene expression in normal tissue: SRSF10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRSF10

DatabasePathway IDPathway Des.
wikipathwaysWP2001miR-targeted genes in adipocytes - TarBase
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP411mRNA Processing
kegghsa03040Spliceosome - Homo sapiens (human)
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRSF10