SRSF10
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine and arginine rich splicing factor 10 | MIM:605221 | Ensembl:ENSG00000188529 | HGNC:HGNC:16713 | PA28427 | 1p36.11 |
GO terms in SRSF10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | NAS | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0050733 | RS domain binding |
| MF | NAS | GO:0051082 | unfolded protein binding |
| BP | NAS | GO:0000244 | spliceosomal tri-snRNP complex assembly |
| BP | IDA | GO:0000375 | RNA splicing, via transesterification reactions |
| BP | IBA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0000395 | mRNA 5'-splice site recognition |
| BP | IDA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006376 | mRNA splice site selection |
| BP | IEA | GO:0016482 | cytosolic transport |
| BP | IBA | GO:0045292 | mRNA cis splicing, via spliceosome |
| BP | IDA | GO:0048024 | regulation of mRNA splicing, via spliceosome |
| BP | IDA | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0016607 | nuclear speck |
Gene expression in normal tissue: SRSF10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRSF10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2001 | miR-targeted genes in adipocytes - TarBase |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP411 | mRNA Processing |
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRSF10
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.