Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010].

serine and arginine rich splicing factor 3MIM:603364Ensembl:ENSG00000112081HGNC:HGNC:10785PA357016p21.31-p21.2

GO terms in SRSF3

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0043274phospholipase binding
MFIEAGO:1990825sequence-specific mRNA binding
BPIBAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006405RNA export from nucleus
BPIDAGO:0006406mRNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPTASGO:0031124mRNA 3'-end processing
BPIBAGO:0045292mRNA cis splicing, via spliceosome
BPIDAGO:0048024regulation of mRNA splicing, via spliceosome
BPIEAGO:1990830cellular response to leukemia inhibitory factor
CCIBAGO:0016607nuclear speck
CCIDAGO:0016607nuclear speck

Gene expression in normal tissue: SRSF3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRSF3

DatabasePathway IDPathway Des.
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
wikipathwaysWP411mRNA Processing
kegghsa03040Spliceosome - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRSF3