SSH1
Summary: The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| slingshot protein phosphatase 1 | MIM:606778 | Ensembl:ENSG00000084112 | HGNC:HGNC:30579 | PA134941788 | 12q24.11 |
GO terms in SSH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000902 | cell morphogenesis |
| BP | IMP | GO:0006470 | protein dephosphorylation |
| BP | IBA | GO:0008064 | regulation of actin polymerization or depolymerization |
| BP | IBA | GO:0010591 | regulation of lamellipodium assembly |
| BP | IMP | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0031915 | positive regulation of synaptic plasticity |
| BP | IDA | GO:0032268 | regulation of cellular protein metabolic process |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IBA | GO:0050770 | regulation of axonogenesis |
| BP | IDA | GO:0071318 | cellular response to ATP |
| BP | IEA | GO:0098976 | excitatory chemical synaptic transmission |
| BP | IEA | GO:1901216 | positive regulation of neuron death |
| BP | IEA | GO:1904719 | positive regulation of AMPA glutamate receptor clustering |
| BP | IEA | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| BP | IEA | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0030426 | growth cone |
| CC | IEA | GO:0030496 | midbody |
| CC | IEA | GO:0032154 | cleavage furrow |
| MF | IBA | GO:0003779 | actin binding |
| MF | IDA | GO:0003779 | actin binding |
| MF | IDA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IMP | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IEA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
Gene expression in normal tissue: SSH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SSH1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | fgf_pathway | FGF signaling pathway |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SSH1
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