SSH1


Summary: The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
slingshot protein phosphatase 1MIM:606778Ensembl:ENSG00000084112HGNC:HGNC:30579PA13494178812q24.11

GO terms in SSH1


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000902cell morphogenesis
BPIMPGO:0006470protein dephosphorylation
BPIBAGO:0008064regulation of actin polymerization or depolymerization
BPIBAGO:0010591regulation of lamellipodium assembly
BPIMPGO:0030036actin cytoskeleton organization
BPIEAGO:0031915positive regulation of synaptic plasticity
BPIDAGO:0032268regulation of cellular protein metabolic process
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
BPIBAGO:0050770regulation of axonogenesis
BPIDAGO:0071318cellular response to ATP
BPIEAGO:0098976excitatory chemical synaptic transmission
BPIEAGO:1901216positive regulation of neuron death
BPIEAGO:1904719positive regulation of AMPA glutamate receptor clustering
BPIEAGO:1904754positive regulation of vascular associated smooth muscle cell migration
BPIEAGO:2000463positive regulation of excitatory postsynaptic potential
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCIDAGO:0005886plasma membrane
CCIEAGO:0030027lamellipodium
CCIEAGO:0030426growth cone
CCIEAGO:0030496midbody
CCIEAGO:0032154cleavage furrow
MFIBAGO:0003779actin binding
MFIDAGO:0003779actin binding
MFIDAGO:0004721phosphoprotein phosphatase activity
MFIMPGO:0004721phosphoprotein phosphatase activity
MFIEAGO:0004725protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIEAGO:0008138protein tyrosine/serine/threonine phosphatase activity

Gene expression in normal tissue: SSH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SSH1


DatabasePathway IDPathway Des.
pidcxcr4_pathwayCXCR4-mediated signaling events
pidfgf_pathwayFGF signaling pathway
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
wikipathwaysWP51Regulation of Actin Cytoskeleton

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SSH1

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