STEAP2
Summary: This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| STEAP2 metalloreductase | MIM:605094 | Ensembl:ENSG00000157214 | HGNC:HGNC:17885 | PA38473 | 7q21.13 |
Gene Categories:
TRANSPORTERGO terms in STEAP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006893 | Golgi to plasma membrane transport |
| BP | IDA | GO:0006897 | endocytosis |
| BP | IDA | GO:0009725 | response to hormone |
| BP | IBA | GO:0015677 | copper ion import |
| BP | IDA | GO:0045055 | regulated exocytosis |
| BP | IEA | GO:0055072 | iron ion homeostasis |
| BP | IBA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IBA | GO:0098706 | ferric iron import across plasma membrane |
| CC | IBA | GO:0005768 | endosome |
| CC | IDA | GO:0005769 | early endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0010008 | endosome membrane |
| CC | IDA | GO:0030140 | trans-Golgi network transport vesicle |
| CC | IDA | GO:0030173 | integral component of Golgi membrane |
| MF | IDA | GO:0005215 | transporter activity |
| MF | IBA | GO:0008823 | cupric reductase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0052851 | ferric-chelate reductase (NADPH) activity |
Gene expression in normal tissue: STEAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STEAP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3286 | Copper homeostasis |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-917937 | Iron uptake and transport |
| reactome | R-HSA-917977 | Transferrin endocytosis and recycling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STEAP2
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