STMN1
Summary: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namestathmin 1 OMIM IDMIM:151442 Ensembl IDEnsembl:ENSG00000117632 HGNC IDHGNC:HGNC:6510 PHARMGKB IDPA35491 Map Location1p36.11 | |||||
GO terms in STMN1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015631 | tubulin binding |
| MF | IDA | GO:0015631 | tubulin binding |
| MF | IMP | GO:0015631 | tubulin binding |
| BP | IMP | GO:0000281 | mitotic cytokinesis |
| BP | IBA | GO:0007019 | microtubule depolymerization |
Gene expression in normal tissue: STMN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STMN1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STMN1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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