STMN1


Summary: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:151442
PHARMGKB IDPA35491
Map Location1p36.11

GO terms in STMN1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0015631 tubulin binding
MF IDA GO:0015631 tubulin binding
MF IMP GO:0015631 tubulin binding
BP IMP GO:0000281 mitotic cytokinesis
BP IBA GO:0007019 microtubule depolymerization
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Gene expression in normal tissue: STMN1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STMN1


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Database
Pathway ID
Pathway Des.
wikipathways WP2038 Regulation of Microtubule Cytoskeleton
wikipathways WP2446 Retinoblastoma (RB) in Cancer
wikipathways WP3303 Rac1-Pak1-p38-MMP-2 pathway
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP437 EGF-EGFR Signaling Pathway
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STMN1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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