SUCLG2


Summary: This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
succinate-CoA ligase GDP-forming beta subunitMIM:603922Ensembl:ENSG00000172340HGNC:HGNC:11450PA362473p14.1

GO terms in SUCLG2


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0004776succinate-CoA ligase (GDP-forming) activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0005525GTP binding
MFIEAGO:0019003GDP binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0046982protein heterodimerization activity
BPIEAGO:0006099tricarboxylic acid cycle
BPNASGO:0006104succinyl-CoA metabolic process
BPIEAGO:0006105succinate metabolic process
CCIDAGO:0005739mitochondrion
CCTASGO:0005759mitochondrial matrix
CCIDAGO:0005886plasma membrane
CCIEAGO:0045244succinate-CoA ligase complex (GDP-forming)

Gene expression in normal tissue: SUCLG2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SUCLG2


DatabasePathway IDPathway Des.
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2453TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
wikipathwaysWP78TCA Cycle
smpdbSMP00057Citric Acid Cycle
smpdbSMP00546Congenital lactic acidosis
smpdbSMP00547Fumarase deficiency
smpdbSMP00548Mitochondrial complex II deficiency
smpdbSMP005492-ketoglutarate dehydrogenase complex deficiency
smpdbSMP00550Pyruvate dehydrogenase deficiency (E3)
smpdbSMP00551Pyruvate dehydrogenase deficiency (E2)
smpdbSMP00654Warburg Effect
smpdbSMP02291The oncogenic action of 2-hydroxyglutarate
smpdbSMP02292The oncogenic action of Succinate
smpdbSMP02295The oncogenic action of Fumarate
smpdbSMP02298Glutaminolysis and Cancer
smpdbSMP02358The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria
smpdbSMP02359The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria
humancycPWY66-398TCA cycle
humancycPWY66-407superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
pharmgkbPA165959313Valproic Acid Pathway, Pharmacodynamics
pharmgkbPA165964473Pathway_PA165964473
kegghsa00020Citrate cycle (TCA cycle) - Homo sapiens (human)
kegghsa00640Propanoate metabolism - Homo sapiens (human)
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-71403Citric acid cycle (TCA cycle)
reactomeR-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUCLG2

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