SUCLG2
Summary: This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| succinate-CoA ligase GDP-forming beta subunit | MIM:603922 | Ensembl:ENSG00000172340 | HGNC:HGNC:11450 | PA36247 | 3p14.1 |
GO terms in SUCLG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0019003 | GDP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| BP | IEA | GO:0006099 | tricarboxylic acid cycle |
| BP | NAS | GO:0006104 | succinyl-CoA metabolic process |
| BP | IEA | GO:0006105 | succinate metabolic process |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
Gene expression in normal tissue: SUCLG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SUCLG2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2453 | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| wikipathways | WP78 | TCA Cycle |
| smpdb | SMP00057 | Citric Acid Cycle |
| smpdb | SMP00546 | Congenital lactic acidosis |
| smpdb | SMP00547 | Fumarase deficiency |
| smpdb | SMP00548 | Mitochondrial complex II deficiency |
| smpdb | SMP00549 | 2-ketoglutarate dehydrogenase complex deficiency |
| smpdb | SMP00550 | Pyruvate dehydrogenase deficiency (E3) |
| smpdb | SMP00551 | Pyruvate dehydrogenase deficiency (E2) |
| smpdb | SMP00654 | Warburg Effect |
| smpdb | SMP02291 | The oncogenic action of 2-hydroxyglutarate |
| smpdb | SMP02292 | The oncogenic action of Succinate |
| smpdb | SMP02295 | The oncogenic action of Fumarate |
| smpdb | SMP02298 | Glutaminolysis and Cancer |
| smpdb | SMP02358 | The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria |
| smpdb | SMP02359 | The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria |
| humancyc | PWY66-398 | TCA cycle |
| humancyc | PWY66-407 | superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle |
| pharmgkb | PA165959313 | Valproic Acid Pathway, Pharmacodynamics |
| pharmgkb | PA165964473 | Pathway_PA165964473 |
| kegg | hsa00020 | Citrate cycle (TCA cycle) - Homo sapiens (human) |
| kegg | hsa00640 | Propanoate metabolism - Homo sapiens (human) |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-71403 | Citric acid cycle (TCA cycle) |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SUCLG2
CLASSFICATION
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