SURF4


Summary: This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
surfeit 4MIM:185660Ensembl:ENSG00000148248HGNC:HGNC:11476PA362619q34.2

GO terms in SURF4


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
BPTASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIMPGO:0007030Golgi organization
BPIMPGO:0010638positive regulation of organelle organization
BPIMPGO:0032527protein exit from endoplasmic reticulum
BPIMPGO:0034498early endosome to Golgi transport
BPTASGO:0043312neutrophil degranulation
CCTASGO:0000139Golgi membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0030133transport vesicle
CCIEAGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane
CCTASGO:0035577azurophil granule membrane

Gene expression in normal tissue: SURF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SURF4


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SURF4

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