SUV39H1


Summary: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
suppressor of variegation 3-9 homolog 1MIM:300254Ensembl:ENSG00000101945HGNC:HGNC:11479PA36264Xp11.23

GO terms in SUV39H1


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000183chromatin silencing at rDNA
BPTASGO:0000183chromatin silencing at rDNA
BPTASGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006364rRNA processing
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007049cell cycle
BPIEAGO:0016032viral process
BPIEAGO:0030154cell differentiation
BPISSGO:0036123histone H3-K9 dimethylation
BPISSGO:0036124histone H3-K9 trimethylation
BPISSGO:0042754negative regulation of circadian rhythm
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0048511rhythmic process
BPIDAGO:0071456cellular response to hypoxia
CCIEAGO:0000775chromosome, centromeric region
CCIDAGO:0000792heterochromatin
CCTASGO:0000794condensed nuclear chromosome
CCIDAGO:0005634nucleus
CCIEAGO:0005652nuclear lamina
CCTASGO:0005654nucleoplasm
CCIDAGO:0005677chromatin silencing complex
CCIDAGO:0033553rDNA heterochromatin
MFISSGO:0000976transcription regulatory region sequence-specific DNA binding
MFTASGO:0003682chromatin binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIDAGO:0008757S-adenosylmethionine-dependent methyltransferase activity
MFIDAGO:0018024histone-lysine N-methyltransferase activity
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIDAGO:0042054histone methyltransferase activity
MFEXPGO:0046974histone methyltransferase activity (H3-K9 specific)
MFIDAGO:0046974histone methyltransferase activity (H3-K9 specific)
MFIPIGO:0047485protein N-terminus binding

Gene expression in normal tissue: SUV39H1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SUV39H1


DatabasePathway IDPathway Des.
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-427359SIRT1 negatively regulates rRNA expression
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-74160Gene expression (Transcription)
kegghsa00310Lysine degradation - Homo sapiens (human)
pidrb_1pathwayRegulation of retinoblastoma protein
wikipathwaysWP2369Histone Modifications
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP3670Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUV39H1

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