SUV39H1
Summary: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
suppressor of variegation 3-9 homolog 1 | MIM:300254 | Ensembl:ENSG00000101945 | HGNC:HGNC:11479 | PA36264 | Xp11.23 |
GO terms in SUV39H1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IDA | GO:0000183 | chromatin silencing at rDNA |
BP | TAS | GO:0000183 | chromatin silencing at rDNA |
BP | TAS | GO:0006325 | chromatin organization |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEA | GO:0006364 | rRNA processing |
BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
BP | IEA | GO:0007049 | cell cycle |
BP | IEA | GO:0016032 | viral process |
BP | IEA | GO:0030154 | cell differentiation |
BP | ISS | GO:0036123 | histone H3-K9 dimethylation |
BP | ISS | GO:0036124 | histone H3-K9 trimethylation |
BP | ISS | GO:0042754 | negative regulation of circadian rhythm |
BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
BP | IEA | GO:0048511 | rhythmic process |
BP | IDA | GO:0071456 | cellular response to hypoxia |
CC | IEA | GO:0000775 | chromosome, centromeric region |
CC | IDA | GO:0000792 | heterochromatin |
CC | TAS | GO:0000794 | condensed nuclear chromosome |
CC | IDA | GO:0005634 | nucleus |
CC | IEA | GO:0005652 | nuclear lamina |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005677 | chromatin silencing complex |
CC | IDA | GO:0033553 | rDNA heterochromatin |
MF | ISS | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
MF | TAS | GO:0003682 | chromatin binding |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008270 | zinc ion binding |
MF | IDA | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity |
MF | IDA | GO:0018024 | histone-lysine N-methyltransferase activity |
MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
MF | IDA | GO:0042054 | histone methyltransferase activity |
MF | EXP | GO:0046974 | histone methyltransferase activity (H3-K9 specific) |
MF | IDA | GO:0046974 | histone methyltransferase activity (H3-K9 specific) |
MF | IPI | GO:0047485 | protein N-terminus binding |
Gene expression in normal tissue: SUV39H1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SUV39H1
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
reactome | R-HSA-3247509 | Chromatin modifying enzymes |
reactome | R-HSA-427359 | SIRT1 negatively regulates rRNA expression |
reactome | R-HSA-4839726 | Chromatin organization |
reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
reactome | R-HSA-74160 | Gene expression (Transcription) |
kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
pid | rb_1pathway | Regulation of retinoblastoma protein |
wikipathways | WP2369 | Histone Modifications |
wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
wikipathways | WP3670 | Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SUV39H1