SYNE2


Summary: The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
spectrin repeat containing nuclear envelope protein 2MIM:608442Ensembl:ENSG00000054654HGNC:HGNC:17084PA12839461314q23.2

GO terms in SYNE2


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0003779actin binding
MFIPIGO:0005515protein binding
MFIEAGO:0051015actin filament binding
CCIDAGO:0005634nucleus
CCIDAGO:0005635nuclear envelope
CCIEAGO:0005640nuclear outer membrane
CCIEAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIBAGO:0005813centrosome
CCIDAGO:0005925focal adhesion
CCIEAGO:0016021integral component of membrane
CCIDAGO:0016235aggresome
CCIDAGO:0016529sarcoplasmic reticulum
CCIDAGO:0030018Z disc
CCIDAGO:0031258lamellipodium membrane
CCIDAGO:0031527filopodium membrane
CCIDAGO:0031965nuclear membrane
CCIDAGO:0031981nuclear lumen
CCIEAGO:0033017sarcoplasmic reticulum membrane
CCIDAGO:0034993meiotic nuclear membrane microtubule tethering complex
CCIDAGO:0045111intermediate filament cytoskeleton
CCHDAGO:0070062extracellular exosome
BPIEAGO:0006998nuclear envelope organization
BPIMPGO:0007097nuclear migration
BPIEAGO:0007163establishment or maintenance of cell polarity
BPIBAGO:0010457centriole-centriole cohesion
BPIEAGO:0010761fibroblast migration
BPIEAGO:0021817nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
BPISSGO:0030335positive regulation of cell migration
BPISSGO:0031022nuclear migration along microfilament
BPIEAGO:0034504protein localization to nucleus
BPIMPGO:0051642centrosome localization
BPIDAGO:0090286cytoskeletal anchoring at nuclear membrane
BPIEAGO:1902017regulation of cilium assembly

Gene expression in normal tissue: SYNE2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SYNE2


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP34Ovarian Infertility Genes
reactomeR-HSA-1221632Meiotic synapsis
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-1640170Cell Cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SYNE2

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