SYNE2
Summary: The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| spectrin repeat containing nuclear envelope protein 2 | MIM:608442 | Ensembl:ENSG00000054654 | HGNC:HGNC:17084 | PA128394613 | 14q23.2 |
GO terms in SYNE2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0051015 | actin filament binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IEA | GO:0005640 | nuclear outer membrane |
| CC | IEA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016235 | aggresome |
| CC | IDA | GO:0016529 | sarcoplasmic reticulum |
| CC | IDA | GO:0030018 | Z disc |
| CC | IDA | GO:0031258 | lamellipodium membrane |
| CC | IDA | GO:0031527 | filopodium membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0031981 | nuclear lumen |
| CC | IEA | GO:0033017 | sarcoplasmic reticulum membrane |
| CC | IDA | GO:0034993 | meiotic nuclear membrane microtubule tethering complex |
| CC | IDA | GO:0045111 | intermediate filament cytoskeleton |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0006998 | nuclear envelope organization |
| BP | IMP | GO:0007097 | nuclear migration |
| BP | IEA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | IBA | GO:0010457 | centriole-centriole cohesion |
| BP | IEA | GO:0010761 | fibroblast migration |
| BP | IEA | GO:0021817 | nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration |
| BP | ISS | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0031022 | nuclear migration along microfilament |
| BP | IEA | GO:0034504 | protein localization to nucleus |
| BP | IMP | GO:0051642 | centrosome localization |
| BP | IDA | GO:0090286 | cytoskeletal anchoring at nuclear membrane |
| BP | IEA | GO:1902017 | regulation of cilium assembly |
Gene expression in normal tissue: SYNE2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SYNE2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP34 | Ovarian Infertility Genes |
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1640170 | Cell Cycle |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SYNE2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.