Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

TATA-box binding protein associated factor 9MIM:600822Ensembl:ENSG00000273841HGNC:HGNC:11542PA363175q13.2

GO terms in TAF9

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001075transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
MFIPIGO:0002039p53 binding
MFIDAGO:0003677DNA binding
MFIDAGO:0003713transcription coactivator activity
MFIMPGO:0003713transcription coactivator activity
MFIBAGO:0004402histone acetyltransferase activity
MFIDAGO:0004402histone acetyltransferase activity
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0033613activating transcription factor binding
MFIBAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046982protein heterodimerization activity
MFIPIGO:0051117ATPase binding
MFIPIGO:0070742C2H2 zinc finger domain binding
BPIDAGO:0000492box C/D snoRNP assembly
BPIBAGO:0006366transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPICGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0030307positive regulation of cell growth
BPIDAGO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BPTASGO:0042795snRNA transcription by RNA polymerase II
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0043966histone H3 acetylation
BPIDAGO:0043966histone H3 acetylation
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0050821protein stabilization
BPIEAGO:0051123RNA polymerase II transcriptional preinitiation complex assembly
BPIMPGO:0060760positive regulation of response to cytokine stimulus
BPIMPGO:0070555response to interleukin-1
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPICGO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
CCIBAGO:0000124SAGA complex
CCIDAGO:0000125PCAF complex
CCIBAGO:0005669transcription factor TFIID complex
CCIDAGO:0005669transcription factor TFIID complex
CCIDAGO:0030914STAGA complex
CCIDAGO:0033276transcription factor TFTC complex
CCIDAGO:0070761pre-snoRNP complex
CCIDAGO:0071339MLL1 complex

Gene expression in normal tissue: TAF9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAF9

DatabasePathway IDPathway Des.
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance
wikipathwaysWP405Eukaryotic Transcription Initiation
kegghsa03022Basal transcription factors - Homo sapiens (human)
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidmyc_pathwayC-MYC pathway
pidp53downstreampathwayDirect p53 effectors

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAF9