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Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
TRAF family member associated NFKB activator	MIM:603893	Ensembl:ENSG00000136560	HGNC:HGNC:11562	PA36330	2q24.2

Gene Categories:

PROTEASE

GO terms in TANK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IMP	GO:0004843	thiol-dependent ubiquitin-specific protease activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0031625	ubiquitin protein ligase binding
MF	IMP	GO:0035800	deubiquitinase activator activity
MF	IEA	GO:0046872	metal ion binding
BP	IEA	GO:0006508	proteolysis
BP	IMP	GO:0006974	cellular response to DNA damage stimulus
BP	TAS	GO:0007165	signal transduction
BP	IBA	GO:0007249	I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0007249	I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0016032	viral process
BP	TAS	GO:0035666	TRIF-dependent toll-like receptor signaling pathway
BP	IMP	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
BP	IMP	GO:0071347	cellular response to interleukin-1
BP	IMP	GO:0071356	cellular response to tumor necrosis factor
BP	IMP	GO:0071479	cellular response to ionizing radiation
BP	IMP	GO:1903003	positive regulation of protein deubiquitination
BP	IMP	GO:2000158	positive regulation of ubiquitin-specific protease activity
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0032991	protein-containing complex

Gene expression in normal tissue: TANK

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TANK

Database	Pathway ID	Pathway Des.
kegg	hsa04621	NOD-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04622	RIG-I-like receptor signaling pathway - Homo sapiens (human)
netpath	Pathway_TNFalpha	TNFalpha
wikipathways	WP231	TNF alpha Signaling Pathway
wikipathways	WP2637	Structural Pathway of Interleukin 1 (IL-1)
wikipathways	WP3865	RIG-I-like Receptor Signaling
reactome	R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade
reactome	R-HSA-166166	MyD88-independent TLR4 cascade
reactome	R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168898	Toll-Like Receptors Cascades
reactome	R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactome	R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7
reactome	R-HSA-933541	TRAF6 mediated IRF7 activation
reactome	R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
reactome	R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling
biocarta	stresspathway	tnf/stress related signaling
biocarta	tnfr2pathway	tnfr2 signaling pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD158	NSC141540	3
iGMDRD121	GMX1778	2
iGMDRD137	Indisulam	3
iGMDRD213	SMR000068650	2
iGMDRD289	Parthenolide	1
iGMDRD329	Merck60	2
iGMDRD871	BRD6368	2
iGMDRD367	Ro 28-1675	2
iGMDRD79	Gemcitabine	3
iGMDRD532	Olaparib	4
iGMDRD560	MK-2206	1
iGMDRD945	ML214	5
iGMDRD123	Isoevodiamine	2
iGMDRD187	BRD9876	2
iGMDRD294	Batimastat	2
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD171	Pemetrexed	2
iGMDRD780	PP-30	3
iGMDRD506	Fedratinib	2
iGMDRD74	Idarubicin	5
iGMDRD730	Kahalalide F	2
iGMDRD188	Piperlongumine	3
iGMDRD23	Gossypol	2
iGMDRD64	Parbendazole	2
iGMDRD425	ERASTIN	2
iGMDRD889	Compound 7d-cis	5
iGMDRD126	Tipifarnib	5
iGMDRD781	Sirolimus	8
iGMDRD546	BMS-754807	2
iGMDRD639	YK 4-279	2
iGMDRD394	BX-795	2
iGMDRD679	Bistramide A	1
iGMDRD220	fumonisin B1	1
iGMDRD481	Dactolisib	2
iGMDRD434	BMS-536924	5
iGMDRD6	AM-580	2
iGMDRD882	CIL41	2
iGMDRD300	Tozasertib	2
iGMDRD148	Pifithrin-mu	1
iGMDRD607	Ubistatin B	2
iGMDRD512	nutlin 3	3
iGMDRD307	Manumycin A	2
iGMDRD84	Lovastatin acid	3
iGMDRD701	NVP-AUY922	1
iGMDRD345	Compound 10b [PMID: 11504634]	2
iGMDRD424	Tamatinib	4
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD132	(-)-gallocatechin-3-O-gallate	1
iGMDRD177	Teniposide	2
iGMDRD255	SB225002	3
iGMDRD270	Ciclosporin	2
iGMDRD870	BRD63610	3
iGMDRD885	Compound 110	2
iGMDRD441	TW 37	2
iGMDRD318	PAC-1	4
iGMDRD562	Navitoclax	6
iGMDRD577	BIX01294	10
iGMDRD887	Compound 23 citrate	2
iGMDRD444	Tivantinib	2
iGMDRD451	Serdemetan	3
iGMDRD60	Quinoclamine	2
iGMDRD690	PRIMA-1MET	4
iGMDRD772	BRD4770	6
iGMDRD193	Fqi1	2
iGMDRD446	LY 2183240	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD297	Austocystin D	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TANK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.