TANK


Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TRAF family member associated NFKB activatorMIM:603893Ensembl:ENSG00000136560HGNC:HGNC:11562PA363302q24.2

Gene Categories:

PROTEASE

GO terms in TANK


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIPIGO:0005515protein binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIMPGO:0035800deubiquitinase activator activity
MFIEAGO:0046872metal ion binding
BPIEAGO:0006508proteolysis
BPIMPGO:0006974cellular response to DNA damage stimulus
BPTASGO:0007165signal transduction
BPIBAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0016032viral process
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPIMPGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0071347cellular response to interleukin-1
BPIMPGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0071479cellular response to ionizing radiation
BPIMPGO:1903003positive regulation of protein deubiquitination
BPIMPGO:2000158positive regulation of ubiquitin-specific protease activity
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0032991protein-containing complex

Gene expression in normal tissue: TANK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TANK


DatabasePathway IDPathway Des.
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
netpathPathway_TNFalphaTNFalpha
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP3865RIG-I-like Receptor Signaling
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-9013973TICAM1-dependent activation of IRF3/IRF7
reactomeR-HSA-933541TRAF6 mediated IRF7 activation
reactomeR-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
biocartastresspathwaytnf/stress related signaling
biocartatnfr2pathwaytnfr2 signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD158NSC1415403
iGMDRD121GMX17782
iGMDRD137Indisulam3
iGMDRD213SMR0000686502
iGMDRD289Parthenolide1
iGMDRD329Merck602
iGMDRD871BRD63682
iGMDRD367Ro 28-16752
iGMDRD79Gemcitabine3
iGMDRD532Olaparib4
iGMDRD560MK-22061
iGMDRD945ML2145
iGMDRD123Isoevodiamine2
iGMDRD187BRD98762
iGMDRD294Batimastat2
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD171Pemetrexed2
iGMDRD780PP-303
iGMDRD506Fedratinib2
iGMDRD74Idarubicin5
iGMDRD730Kahalalide F2
iGMDRD188Piperlongumine3
iGMDRD23Gossypol2
iGMDRD64Parbendazole2
iGMDRD425ERASTIN2
iGMDRD889Compound 7d-cis5
iGMDRD126Tipifarnib5
iGMDRD781Sirolimus8
iGMDRD546BMS-7548072
iGMDRD639YK 4-2792
iGMDRD394BX-7952
iGMDRD679Bistramide A1
iGMDRD220fumonisin B11
iGMDRD481Dactolisib2
iGMDRD434BMS-5369245
iGMDRD6AM-5802
iGMDRD882CIL412
iGMDRD300Tozasertib2
iGMDRD148Pifithrin-mu1
iGMDRD607Ubistatin B2
iGMDRD512nutlin 33
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid3
iGMDRD701NVP-AUY9221
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD424Tamatinib4
iGMDRD57Chloropentafluorobenzene2
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD177Teniposide2
iGMDRD255SB2250023
iGMDRD270Ciclosporin2
iGMDRD870BRD636103
iGMDRD885Compound 1102
iGMDRD441TW 372
iGMDRD318PAC-14
iGMDRD562Navitoclax6
iGMDRD577BIX0129410
iGMDRD887Compound 23 citrate2
iGMDRD444Tivantinib2
iGMDRD451Serdemetan3
iGMDRD60Quinoclamine2
iGMDRD690PRIMA-1MET4
iGMDRD772BRD47706
iGMDRD193Fqi12
iGMDRD446LY 21832402
iGMDRD280CYTOCHALASIN B2
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TANK

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