TARDBP


Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TAR DNA binding proteinMIM:605078Ensembl:ENSG00000120948HGNC:HGNC:11571PA363361p36.22

Gene Categories:

TUMOR SUPPRESSOR

GO terms in TARDBP


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005726perichromatin fibrils
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
CCIEAGO:0016607nuclear speck
CCIEAGO:0035061interchromatin granule
BPIMPGO:0001933negative regulation of protein phosphorylation
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0006397mRNA processing
BPIDAGO:0008380RNA splicing
BPIMPGO:0010629negative regulation of gene expression
BPIEAGO:0032024positive regulation of insulin secretion
BPIEAGO:0034976response to endoplasmic reticulum stress
BPIMPGO:0042981regulation of apoptotic process
BPIDAGO:0043922negative regulation by host of viral transcription
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0051252regulation of RNA metabolic process
BPIMPGO:0051726regulation of cell cycle
BPIBAGO:00709353'-UTR-mediated mRNA stabilization
BPIDAGO:00709353'-UTR-mediated mRNA stabilization
BPIMPGO:0071765nuclear inner membrane organization
MFIBAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIEAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIBAGO:0003690double-stranded DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIBAGO:0003727single-stranded RNA binding
MFIBAGO:0003730mRNA 3'-UTR binding
MFIDAGO:0003730mRNA 3'-UTR binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: TARDBP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TARDBP


DatabasePathway IDPathway Des.
wikipathwaysWP3987HDAC6 interactions

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TARDBP

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