TCIRG1


Summary: This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3MIM:604592Ensembl:ENSG00000110719HGNC:HGNC:11647PA3639911q13.2

GO terms in TCIRG1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006968cellular defense response
BPIBAGO:0007035vacuolar acidification
BPISSGO:0007039protein catabolic process in the vacuole
BPTASGO:0008284positive regulation of cell proliferation
BPTASGO:0008286insulin receptor signaling pathway
BPIEAGO:0015991ATP hydrolysis coupled proton transport
BPISSGO:0016236macroautophagy
BPTASGO:0033572transferrin transport
BPTASGO:0034220ion transmembrane transport
BPTASGO:0043312neutrophil degranulation
BPTASGO:1902600proton transmembrane transport
CCIEAGO:0000220vacuolar proton-transporting V-type ATPase, V0 domain
CCHDAGO:0005765lysosomal membrane
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0010008endosome membrane
CCIDAGO:0016324apical plasma membrane
CCIBAGO:0016471vacuolar proton-transporting V-type ATPase complex
CCTASGO:0030670phagocytic vesicle membrane
CCTASGO:0101003ficolin-1-rich granule membrane
MFTASGO:0005215transporter activity
MFIBAGO:0046961proton-transporting ATPase activity, rotational mechanism
MFIBAGO:0051117ATPase binding

Gene expression in normal tissue: TCIRG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TCIRG1


DatabasePathway IDPathway Des.
kegghsa00190Oxidative phosphorylation - Homo sapiens (human)
kegghsa04142Lysosome - Homo sapiens (human)
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04721Synaptic vesicle cycle - Homo sapiens (human)
kegghsa04966Collecting duct acid secretion - Homo sapiens (human)
kegghsa05110Vibrio cholerae infection - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
wikipathwaysWP3945TYROBP Causal Network
reactomeR-HSA-1222556ROS, RNS production in phagocytes
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-77387Insulin receptor recycling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-917937Iron uptake and transport
reactomeR-HSA-917977Transferrin endocytosis and recycling
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCIRG1

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