TCN1


Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transcobalamin 1MIM:189905Ensembl:ENSG00000134827HGNC:HGNC:11652PA3640311q12.1

Gene Categories:

DRUGGABLE GENOME

GO terms in TCN1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0031419cobalamin binding
BPIEAGO:0006824cobalt ion transport
BPTASGO:0009235cobalamin metabolic process
BPIEAGO:0015889cobalamin transport
BPTASGO:0043312neutrophil degranulation
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCTASGO:0035580specific granule lumen
CCTASGO:1904724tertiary granule lumen

Gene expression in normal tissue: TCN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TCN1


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolism
reactomeR-HSA-196849Metabolism of water-soluble vitamins and cofactors
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-6798695Neutrophil degranulation
wikipathwaysWP1533Vitamin B12 Metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCN1

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