TCN1
Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
transcobalamin 1 | MIM:189905 | Ensembl:ENSG00000134827 | HGNC:HGNC:11652 | PA36403 | 11q12.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TCN1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0031419 | cobalamin binding |
BP | IEA | GO:0006824 | cobalt ion transport |
BP | TAS | GO:0009235 | cobalamin metabolic process |
BP | IEA | GO:0015889 | cobalamin transport |
BP | TAS | GO:0043312 | neutrophil degranulation |
CC | TAS | GO:0005576 | extracellular region |
CC | HDA | GO:0005615 | extracellular space |
CC | TAS | GO:0035580 | specific granule lumen |
CC | TAS | GO:1904724 | tertiary granule lumen |
Gene expression in normal tissue: TCN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TCN1
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism |
reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
reactome | R-HSA-6798695 | Neutrophil degranulation |
wikipathways | WP1533 | Vitamin B12 Metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TCN1