TENT4A
Summary: The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| terminal nucleotidyltransferase 4A | MIM:605198 | Ensembl:ENSG00000112941 | HGNC:HGNC:16705 | PA33523 | 5p15.31 |
GO terms in TENT4A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006302 | double-strand break repair |
| BP | IBA | GO:0006378 | mRNA polyadenylation |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | TAS | GO:0007062 | sister chromatid cohesion |
| BP | NAS | GO:0007076 | mitotic chromosome condensation |
| BP | IDA | GO:0042493 | response to drug |
| BP | IBA | GO:0043630 | ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process |
| BP | IBA | GO:0071035 | nuclear polyadenylation-dependent rRNA catabolic process |
| BP | IBA | GO:0071036 | nuclear polyadenylation-dependent snoRNA catabolic process |
| BP | IBA | GO:0071037 | nuclear polyadenylation-dependent snRNA catabolic process |
| BP | IBA | GO:0071038 | nuclear polyadenylation-dependent tRNA catabolic process |
| BP | IBA | GO:0071042 | nuclear polyadenylation-dependent mRNA catabolic process |
| BP | IBA | GO:0071044 | histone mRNA catabolic process |
| BP | IBA | GO:0071050 | snoRNA polyadenylation |
| BP | IBA | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0031499 | TRAMP complex |
| CC | IDA | GO:0031965 | nuclear membrane |
| MF | IBA | GO:0004652 | polynucleotide adenylyltransferase activity |
| MF | IEA | GO:0004652 | polynucleotide adenylyltransferase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0043221 | SMC family protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: TENT4A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TENT4A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| smpdb | SMP00478 | Nucleotide Excision Repair |
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TENT4A
CLASSFICATION
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