TENT4A


Summary: The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
terminal nucleotidyltransferase 4AMIM:605198Ensembl:ENSG00000112941HGNC:HGNC:16705PA335235p15.31

GO terms in TENT4A


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0006302double-strand break repair
BPIBAGO:0006378mRNA polyadenylation
BPIEAGO:0006397mRNA processing
BPTASGO:0007062sister chromatid cohesion
BPNASGO:0007076mitotic chromosome condensation
BPIDAGO:0042493response to drug
BPIBAGO:0043630ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process
BPIBAGO:0071035nuclear polyadenylation-dependent rRNA catabolic process
BPIBAGO:0071036nuclear polyadenylation-dependent snoRNA catabolic process
BPIBAGO:0071037nuclear polyadenylation-dependent snRNA catabolic process
BPIBAGO:0071038nuclear polyadenylation-dependent tRNA catabolic process
BPIBAGO:0071042nuclear polyadenylation-dependent mRNA catabolic process
BPIBAGO:0071044histone mRNA catabolic process
BPIBAGO:0071050snoRNA polyadenylation
BPIBAGO:0071051polyadenylation-dependent snoRNA 3'-end processing
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005730nucleolus
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0031499TRAMP complex
CCIDAGO:0031965nuclear membrane
MFIBAGO:0004652polynucleotide adenylyltransferase activity
MFIEAGO:0004652polynucleotide adenylyltransferase activity
MFIEAGO:0005524ATP binding
MFTASGO:0043221SMC family protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: TENT4A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TENT4A


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802957Oncogenic MAPK signaling
smpdbSMP00478Nucleotide Excision Repair
kegghsa03018RNA degradation - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TENT4A

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