TFPI
Summary: This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tissue factor pathway inhibitor | MIM:152310 | Ensembl:ENSG00000003436 | HGNC:HGNC:11760 | PA36475 | 2q32.1 |
GO terms in TFPI
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004866 | endopeptidase inhibitor activity |
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005901 | caveola |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0031090 | organelle membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | TAS | GO:0007598 | blood coagulation, extrinsic pathway |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IDA | GO:0030195 | negative regulation of blood coagulation |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071347 | cellular response to interleukin-1 |
| BP | IEP | GO:0071383 | cellular response to steroid hormone stimulus |
Gene expression in normal tissue: TFPI
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFPI
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | extrinsicpathway | extrinsic prothrombin activation pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-140834 | Extrinsic Pathway of Fibrin Clot Formation |
| reactome | R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP3896 | Dengue-2 Interactions with Complement and Coagulation Cascades |
| wikipathways | WP558 | Complement and Coagulation Cascades |
| kegg | hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFPI
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