TGIF1


Summary: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TGFB induced factor homeobox 1MIM:602630Ensembl:ENSG00000177426HGNC:HGNC:11776PA3648918p11.31

Gene Categories:

DRUG RESISTANCE

GO terms in TGIF1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0007275multicellular organism development
BPIEAGO:0042493response to drug
BPIEAGO:0071363cellular response to growth factor stimulus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIMPGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0070410co-SMAD binding

Gene expression in normal tissue: TGIF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGIF1


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3674Tgif disruption of Shh signaling
wikipathwaysWP560TGF-beta Receptor Signaling
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_EGFR1EGFR1
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidar_pathwayCoregulation of Androgen receptor activity
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGIF1

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