TGM5
Summary: This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transglutaminase 5 | MIM:603805 | Ensembl:ENSG00000104055 | HGNC:HGNC:11781 | PA36494 | 15q15.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TGM5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | TAS | GO:0008544 | epidermis development |
| BP | IEA | GO:0018149 | peptide cross-linking |
| BP | TAS | GO:0070268 | cornification |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| MF | TAS | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: TGM5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TGM5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-6805567 | Keratinization |
| reactome | R-HSA-6809371 | Formation of the cornified envelope |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TGM5
CLASSFICATION
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