THTPA
Summary: This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thiamine triphosphatase | MIM:611612 | Ensembl:ENSG00000259431 | HGNC:HGNC:18987 | PA38774 | 14q11.2 |
GO terms in THTPA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| BP | NAS | GO:0006091 | generation of precursor metabolites and energy |
| BP | TAS | GO:0006772 | thiamine metabolic process |
| BP | IDA | GO:0016311 | dephosphorylation |
| BP | ISS | GO:0042357 | thiamine diphosphate metabolic process |
| BP | TAS | GO:0042723 | thiamine-containing compound metabolic process |
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | TAS | GO:0016787 | hydrolase activity |
| MF | IDA | GO:0050333 | thiamin-triphosphatase activity |
| MF | TAS | GO:0050333 | thiamin-triphosphatase activity |
Gene expression in normal tissue: THTPA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in THTPA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196819 | Vitamin B1 (thiamin) metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| kegg | hsa00730 | Thiamine metabolism - Homo sapiens (human) |
| smpdb | SMP00076 | Thiamine Metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in THTPA
CLASSFICATION
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