Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014].

timeless circadian regulatorMIM:603887Ensembl:ENSG00000111602HGNC:HGNC:11813PA3652012q13.3

Gene Categories:


GO terms in TIMELESS

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000076DNA replication checkpoint
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0002009morphogenesis of an epithelium
BPIBAGO:0006281DNA repair
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0006974cellular response to DNA damage stimulus
BPISSGO:0006974cellular response to DNA damage stimulus
BPISSGO:0007623circadian rhythm
BPTASGO:0009582detection of abiotic stimulus
BPIEAGO:0030324lung development
BPIMPGO:0042127regulation of cell proliferation
BPIMPGO:0042752regulation of circadian rhythm
BPIBAGO:0043111replication fork arrest
BPIMPGO:0044770cell cycle phase transition
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIBAGO:0048478replication fork protection
BPIEAGO:0048754branching morphogenesis of an epithelial tube
BPIEAGO:0051301cell division
BPIMPGO:0072711cellular response to hydroxyurea
BPIMPGO:0072719cellular response to cisplatin
BPIMPGO:1904976cellular response to bleomycin
BPIMPGO:2000781positive regulation of double-strand break repair
CCIBAGO:0000228nuclear chromosome
CCIBAGO:0000790nuclear chromatin
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0031298replication fork protection complex
MFIBAGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: TIMELESS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIMELESS

DatabasePathway IDPathway Des.
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-73894DNA Repair
pidatr_pathwayATR signaling pathway
pidcircadianpathwayCircadian rhythm pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIMELESS