TKT


Summary: This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transketolaseMIM:606781Ensembl:ENSG00000163931HGNC:HGNC:11834PA365373p21.1

Gene Categories:

DRUGGABLE GENOME

GO terms in TKT


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCISSGO:0005777peroxisome
CCTASGO:0005829cytosol
CCIDAGO:0016604nuclear body
CCIDAGO:0016607nuclear speck
CCHDAGO:0031982vesicle
CCIEAGO:0043209myelin sheath
CCHDAGO:0070062extracellular exosome
BPTASGO:0005999xylulose biosynthetic process
BPTASGO:0006098pentose-phosphate shunt
BPNASGO:0009052pentose-phosphate shunt, non-oxidative branch
BPIEAGO:0040008regulation of growth
BPIDAGO:0046166glyceraldehyde-3-phosphate biosynthetic process
MFEXPGO:0004802transketolase activity
MFIDAGO:0004802transketolase activity
MFIPIGO:0005515protein binding
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding
MFIDAGO:0048037cofactor binding

Gene expression in normal tissue: TKT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TKT


DatabasePathway IDPathway Des.
netpathPathway_EGFR1EGFR1
humancycNONOXIPENT-PWYpentose phosphate pathway (non-oxidative branch)
humancycPENTOSE-P-PWYpentose phosphate pathway
kegghsa00030Pentose phosphate pathway - Homo sapiens (human)
smpdbSMP00031Pentose Phosphate Pathway
smpdbSMP00518Glucose-6-phosphate dehydrogenase deficiency
smpdbSMP00519Ribose-5-phosphate isomerase deficiency
smpdbSMP00520Transaldolase deficiency
smpdbSMP00654Warburg Effect
wikipathwaysWP134Pentose Phosphate Pathway
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163754Insulin effects increased synthesis of Xylulose-5-Phosphate
reactomeR-HSA-71336Pentose phosphate pathway
reactomeR-HSA-71387Metabolism of carbohydrates

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TKT

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