TKT
Summary: This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transketolase | MIM:606781 | Ensembl:ENSG00000163931 | HGNC:HGNC:11834 | PA36537 | 3p21.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TKT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005777 | peroxisome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | HDA | GO:0031982 | vesicle |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0005999 | xylulose biosynthetic process |
| BP | TAS | GO:0006098 | pentose-phosphate shunt |
| BP | NAS | GO:0009052 | pentose-phosphate shunt, non-oxidative branch |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IDA | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process |
| MF | EXP | GO:0004802 | transketolase activity |
| MF | IDA | GO:0004802 | transketolase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0048037 | cofactor binding |
Gene expression in normal tissue: TKT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TKT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| humancyc | NONOXIPENT-PWY | pentose phosphate pathway (non-oxidative branch) |
| humancyc | PENTOSE-P-PWY | pentose phosphate pathway |
| kegg | hsa00030 | Pentose phosphate pathway - Homo sapiens (human) |
| smpdb | SMP00031 | Pentose Phosphate Pathway |
| smpdb | SMP00518 | Glucose-6-phosphate dehydrogenase deficiency |
| smpdb | SMP00519 | Ribose-5-phosphate isomerase deficiency |
| smpdb | SMP00520 | Transaldolase deficiency |
| smpdb | SMP00654 | Warburg Effect |
| wikipathways | WP134 | Pentose Phosphate Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate |
| reactome | R-HSA-71336 | Pentose phosphate pathway |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TKT
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.