TLX2


Summary: This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
T cell leukemia homeobox 2MIM:604240Ensembl:ENSG00000115297HGNC:HGNC:5057PA350962p13.1

GO terms in TLX2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001707mesoderm formation
BPIEAGO:0006366transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048484enteric nervous system development
BPIEAGO:0050774negative regulation of dendrite morphogenesis
CCNDGO:0005575cellular_component
CCIEAGO:0005634nucleus
CCIEAGO:0005737cytoplasm
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0043565sequence-specific DNA binding

Gene expression in normal tissue: TLX2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLX2


DatabasePathway IDPathway Des.
wikipathwaysWP2023Cell Differentiation - Index expanded
wikipathwaysWP2029Cell Differentiation - Index
wikipathwaysWP2064Neural Crest Differentiation
pidalk1pathwayALK1 signaling events
pidalk2pathwayALK2 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLX2

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