TNFRSF10D


Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008].

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Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in TNFRSF10D


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004888 transmembrane signaling receptor activity
MF IEA GO:0045569 TRAIL binding
BP TAS GO:0007165 signal transduction
BP TAS GO:0007166 cell surface receptor signaling pathway
BP IEA GO:0033209 tumor necrosis factor-mediated signaling pathway
BP TAS GO:0042981 regulation of apoptotic process
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Gene expression in normal tissue: TNFRSF10D

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF10D


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Database
Pathway ID
Pathway Des.
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP3802 TP53 Regulates Transcription of Cell Death Genes
pid p53downstreampathway Direct p53 effectors
pid trail_pathway TRAIL signaling pathway
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04210 Apoptosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF10D

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Cancer
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No matching records found

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