TNFRSF10D
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603614 Ensembl IDEnsembl:ENSG00000173530 HGNC IDHGNC:HGNC:11907 PHARMGKB IDPA36600 Map Location8p21.3 |
GO terms in TNFRSF10D
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
MF | IEA | GO:0045569 | TRAIL binding |
BP | TAS | GO:0007165 | signal transduction |
BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
BP | IEA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
BP | TAS | GO:0042981 | regulation of apoptotic process |
Gene expression in normal tissue: TNFRSF10D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF10D
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1772 | Apoptosis Modulation and Signaling |
wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
pid | p53downstreampathway | Direct p53 effectors |
pid | trail_pathway | TRAIL signaling pathway |
kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF10D
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |