TNPO1


Summary: This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602901
PHARMGKB IDPA30192
Map Location5q13.2

Gene Categories:

TRANSPORTER

GO terms in TNPO1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IPI GO:0005515 protein binding
MF IBA GO:0008139 nuclear localization sequence binding
MF TAS GO:0008139 nuclear localization sequence binding
MF IEA GO:0008536 Ran GTPase binding
MF IBA GO:0008565 protein transporter activity
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Gene expression in normal tissue: TNPO1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNPO1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1852241 Organelle biogenesis and maintenance
reactome R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
reactome R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
reactome R-HSA-5617833 Cilium Assembly
reactome R-HSA-5620924 Intraflagellar transport
reactome R-HSA-8953854 Metabolism of RNA
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD1002 rTRAIL 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNPO1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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