TONSL
Summary: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
tonsoku like, DNA repair protein | MIM:604546 | Ensembl:ENSG00000160949 | HGNC:HGNC:7801 | PA31605 | 8q24.3 |
Gene Categories:
DNA REPAIRGO terms in TONSL
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0003714 | transcription corepressor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0042393 | histone binding |
BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
BP | IMP | GO:0031297 | replication fork processing |
BP | TAS | GO:0042994 | cytoplasmic sequestering of transcription factor |
BP | IEA | GO:1903507 | negative regulation of nucleic acid-templated transcription |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005662 | DNA replication factor A complex |
CC | IEA | GO:0005737 | cytoplasm |
CC | IDA | GO:0016604 | nuclear body |
CC | IDA | GO:0035101 | FACT complex |
CC | IDA | GO:0042555 | MCM complex |
CC | IDA | GO:0043596 | nuclear replication fork |
Gene expression in normal tissue: TONSL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TONSL
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in TONSL