TONSL


Summary: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tonsoku like, DNA repair proteinMIM:604546Ensembl:ENSG00000160949HGNC:HGNC:7801PA316058q24.3

Gene Categories:

DNA REPAIR

GO terms in TONSL


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIDAGO:0042393histone binding
BPIMPGO:0000724double-strand break repair via homologous recombination
BPIMPGO:0031297replication fork processing
BPTASGO:0042994cytoplasmic sequestering of transcription factor
BPIEAGO:1903507negative regulation of nucleic acid-templated transcription
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005662DNA replication factor A complex
CCIEAGO:0005737cytoplasm
CCIDAGO:0016604nuclear body
CCIDAGO:0035101FACT complex
CCIDAGO:0042555MCM complex
CCIDAGO:0043596nuclear replication fork

Gene expression in normal tissue: TONSL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TONSL


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TONSL

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