TOP3B
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA topoisomerase III beta | MIM:603582 | Ensembl:ENSG00000100038 | HGNC:HGNC:11993 | PA36674 | 22q11.22 |
GO terms in TOP3B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003916 | DNA topoisomerase activity |
| MF | TAS | GO:0003916 | DNA topoisomerase activity |
| MF | IEA | GO:0003917 | DNA topoisomerase type I activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0000793 | condensed chromosome |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| BP | IBA | GO:0006265 | DNA topological change |
| BP | IEA | GO:0007059 | chromosome segregation |
Gene expression in normal tissue: TOP3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TOP3B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TOP3B
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