TPCN1
Summary: Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| two pore segment channel 1 | MIM:609666 | Ensembl:ENSG00000186815 | HGNC:HGNC:18182 | PA134922711 | 12q24.13 |
GO terms in TPCN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005245 | voltage-gated calcium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0072345 | NAADP-sensitive calcium-release channel activity |
| MF | TAS | GO:0072345 | NAADP-sensitive calcium-release channel activity |
| CC | TAS | GO:0005764 | lysosome |
| CC | IDA | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005768 | endosome |
| CC | IDA | GO:0010008 | endosome membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IDA | GO:0010508 | positive regulation of autophagy |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0051209 | release of sequestered calcium ion into cytosol |
Gene expression in normal tissue: TPCN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TPCN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TPCN1
CLASSFICATION
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