TRAPPC2


Summary: The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
trafficking protein particle complex 2MIM:300202Ensembl:ENSG00000196459HGNC:HGNC:23068PA35631Xp22.2

GO terms in TRAPPC2


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCTASGO:0005829cytosol
CCIDAGO:0030008TRAPP complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0048471perinuclear region of cytoplasm
BPIMPGO:0001501skeletal system development
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006355regulation of transcription, DNA-templated
BPNASGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0048208COPII vesicle coating
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFTASGO:0017112Rab guanyl-nucleotide exchange factor activity
MFIPIGO:0044325ion channel binding

Gene expression in normal tissue: TRAPPC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRAPPC2


DatabasePathway IDPathway Des.
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8876198RAB GEFs exchange GTP for GDP on RABs
reactomeR-HSA-9007101Rab regulation of trafficking
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRAPPC2

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