TRIM14


Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tripartite motif containing 14MIM:606556Ensembl:ENSG00000106785HGNC:HGNC:16283PA381139q22.33

GO terms in TRIM14


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIEAGO:0008270zinc ion binding
CCIEAGO:0005741mitochondrial outer membrane
BPIDAGO:0032897negative regulation of viral transcription
BPIDAGO:0045087innate immune response
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity

Gene expression in normal tissue: TRIM14

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIM14


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIM14

​​​​