TRIM26
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 26 | MIM:600830 | Ensembl:ENSG00000234127 | HGNC:HGNC:12962 | PA37544 | 6p22.1 |
GO terms in TRIM26
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016740 | transferase activity |
| MF | NAS | GO:0046872 | metal ion binding |
| CC | ND | GO:0005575 | cellular_component |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| BP | IDA | GO:0045087 | innate immune response |
| BP | IDA | GO:0046597 | negative regulation of viral entry into host cell |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IDA | GO:1902187 | negative regulation of viral release from host cell |
Gene expression in normal tissue: TRIM26
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM26
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM26
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