TSPO
Summary: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| translocator protein | MIM:109610 | Ensembl:ENSG00000100300 | HGNC:HGNC:1158 | PA25473 | 22q13.2 |
GO terms in TSPO
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043229 | intracellular organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006626 | protein targeting to mitochondrion |
| BP | TAS | GO:0006700 | C21-steroid hormone biosynthetic process |
| BP | TAS | GO:0006783 | heme biosynthetic process |
| BP | TAS | GO:0006820 | anion transport |
| BP | IEA | GO:0006821 | chloride transport |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007568 | aging |
| BP | TAS | GO:0008202 | steroid metabolic process |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008347 | glial cell migration |
| BP | IEA | GO:0010042 | response to manganese ion |
| BP | IEA | GO:0010266 | response to vitamin B1 |
| BP | IEA | GO:0010940 | positive regulation of necrotic cell death |
| BP | IEA | GO:0014012 | peripheral nervous system axon regeneration |
| BP | IEA | GO:0030301 | cholesterol transport |
| BP | IEA | GO:0030325 | adrenal gland development |
| BP | IEA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | TAS | GO:0032374 | regulation of cholesterol transport |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IEA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| BP | IEA | GO:0048266 | behavioral response to pain |
| BP | IEA | GO:0050810 | regulation of steroid biosynthetic process |
| BP | IEA | GO:0051901 | positive regulation of mitochondrial depolarization |
| BP | IEA | GO:0051928 | positive regulation of calcium ion transport |
| BP | IEA | GO:0060242 | contact inhibition |
| BP | IEA | GO:0060252 | positive regulation of glial cell proliferation |
| BP | IEA | GO:0060253 | negative regulation of glial cell proliferation |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071294 | cellular response to zinc ion |
| BP | IEA | GO:0071476 | cellular hypotonic response |
| BP | IEA | GO:0072656 | maintenance of protein location in mitochondrion |
| BP | IEA | GO:1903147 | negative regulation of autophagy of mitochondrion |
| BP | IEA | GO:1903579 | negative regulation of ATP metabolic process |
| BP | IEA | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| MF | IEA | GO:0005497 | androgen binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008503 | benzodiazepine receptor activity |
| MF | IBA | GO:0015485 | cholesterol binding |
| MF | TAS | GO:0015485 | cholesterol binding |
| MF | TAS | GO:0017127 | cholesterol transporter activity |
| MF | IEA | GO:0044325 | ion channel binding |
Gene expression in normal tissue: TSPO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSPO
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pharmgkb | PA165111376 | Benzodiazepine Pathway, Pharmacodynamics |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196071 | Metabolism of steroid hormones |
| reactome | R-HSA-196108 | Pregnenolone biosynthesis |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TSPO
CLASSFICATION
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