TUBB3
Summary: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tubulin beta 3 class III | MIM:602661 | Ensembl:ENSG00000258947 | HGNC:HGNC:20772 | PA134953867 | 16q24.3 |
GO terms in TUBB3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0007010 | cytoskeleton organization |
| BP | IBA | GO:0007017 | microtubule-based process |
| BP | IEA | GO:0007017 | microtubule-based process |
| BP | IBA | GO:0007411 | axon guidance |
| BP | IMP | GO:0007411 | axon guidance |
| BP | IBA | GO:0030182 | neuron differentiation |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0071944 | cell periphery |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IBA | GO:0005200 | structural constituent of cytoskeleton |
| MF | IEA | GO:0005200 | structural constituent of cytoskeleton |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0042277 | peptide binding |
Gene expression in normal tissue: TUBB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TUBB3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| wikipathways | WP410 | Exercise-induced Circadian Regulation |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-157858 | Gap junction trafficking and regulation |
| reactome | R-HSA-157858 | Gap junction trafficking and regulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-190828 | Gap junction trafficking |
| reactome | R-HSA-190828 | Gap junction trafficking |
| reactome | R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| reactome | R-HSA-190861 | Gap junction assembly |
| reactome | R-HSA-190861 | Gap junction assembly |
| reactome | R-HSA-190872 | Transport of connexons to the plasma membrane |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC |
| reactome | R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| reactome | R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC |
| reactome | R-HSA-389977 | Post-chaperonin tubulin folding pathway |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620924 | Intraflagellar transport |
| reactome | R-HSA-5626467 | RHO GTPases activate IQGAPs |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
| reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| reactome | R-HSA-983189 | Kinesins |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD331 | Taxane | 1 |
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD50 | Cytarabine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TUBB3
CLASSFICATION
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