TUT1
Summary: This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| terminal uridylyl transferase 1, U6 snRNA-specific | MIM:610641 | Ensembl:ENSG00000149016 | HGNC:HGNC:26184 | PA162407405 | 11q12.3 |
GO terms in TUT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | IDA | GO:0006378 | mRNA polyadenylation |
| BP | IMP | GO:0006378 | mRNA polyadenylation |
| BP | IMP | GO:0016180 | snRNA processing |
| BP | IMP | GO:0071044 | histone mRNA catabolic process |
| BP | IDA | GO:0098789 | pre-mRNA cleavage required for polyadenylation |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IDA | GO:0004652 | polynucleotide adenylyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0050265 | RNA uridylyltransferase activity |
Gene expression in normal tissue: TUT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TUT1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TUT1
CLASSFICATION
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