Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017].

thioredoxin reductase 2MIM:606448Ensembl:ENSG00000184470HGNC:HGNC:18155PA3830222q11.21

Gene Categories:


GO terms in TXNRD2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005759mitochondrial matrix
BPTASGO:0000305response to oxygen radical
BPIEAGO:0022900electron transport chain
BPTASGO:0034599cellular response to oxidative stress
BPIBAGO:0045454cell redox homeostasis
BPIEAGO:0098869cellular oxidant detoxification
MFEXPGO:0004791thioredoxin-disulfide reductase activity
MFIBAGO:0004791thioredoxin-disulfide reductase activity
MFISSGO:0004791thioredoxin-disulfide reductase activity
MFIPIGO:0005515protein binding
MFIEAGO:0009055electron transfer activity
MFIBAGO:0016667oxidoreductase activity, acting on a sulfur group of donors
MFIEAGO:0050660flavin adenine dinucleotide binding

Gene expression in normal tissue: TXNRD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TXNRD2

DatabasePathway IDPathway Des.
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3299685Detoxification of Reactive Oxygen Species
reactomeR-HSA-8953897Cellular responses to external stimuli
humancycTHIOREDOX-PWYthioredoxin pathway
kegghsa00450Selenocompound metabolism - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP28Selenium Metabolism and Selenoproteins
wikipathwaysWP408Oxidative Stress

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TXNRD2