TYROBP


Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TYRO protein tyrosine kinase binding proteinMIM:604142Ensembl:ENSG00000011600HGNC:HGNC:12449PA3710019q13.12

Gene Categories:

CELL SURFACE

GO terms in TYROBP


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0030667secretory granule membrane
BPIEAGO:0002281macrophage activation involved in immune response
BPTASGO:0006968cellular defense response
BPTASGO:0007165signal transduction
BPIEAGO:0007229integrin-mediated signaling pathway
BPIMPGO:0030316osteoclast differentiation
BPTASGO:0035556intracellular signal transduction
BPTASGO:0043312neutrophil degranulation
BPTASGO:0045087innate immune response
BPTASGO:0050776regulation of immune response
BPIEAGO:2001204regulation of osteoclast development
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: TYROBP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TYROBP


DatabasePathway IDPathway Des.
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
netpathPathway_RANKLRANKL
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
wikipathwaysWP3945TYROBP Causal Network
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-391160Signal regulatory protein family interactions
reactomeR-HSA-416700Other semaphorin interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TYROBP

​​​​