UBTF


Summary: This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
upstream binding transcription factorMIM:600673Ensembl:ENSG00000108312HGNC:HGNC:12511PA3715817q21.31

GO terms in UBTF


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001188RNA polymerase I transcriptional preinitiation complex assembly
BPNASGO:0006356regulation of transcription by RNA polymerase I
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIMPGO:0006360transcription by RNA polymerase I
BPTASGO:0006361transcription initiation from RNA polymerase I promoter
BPTASGO:0006363termination of RNA polymerase I transcription
BPISSGO:0045943positive regulation of transcription by RNA polymerase I
BPIDAGO:1902659regulation of glucose mediated signaling pathway
CCIDAGO:0001650fibrillar center
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCISSGO:0005730nucleolus
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001164RNA polymerase I CORE element sequence-specific DNA binding
MFIDAGO:0001165RNA polymerase I upstream control element sequence-specific DNA binding
MFIDAGO:0003682chromatin binding
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0097110scaffold protein binding

Gene expression in normal tissue: UBTF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UBTF


DatabasePathway IDPathway Des.
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-427413NoRC negatively regulates rRNA expression
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-73728RNA Polymerase I Promoter Opening
reactomeR-HSA-73762RNA Polymerase I Transcription Initiation
reactomeR-HSA-73772RNA Polymerase I Promoter Escape
reactomeR-HSA-73777RNA Polymerase I Chain Elongation
reactomeR-HSA-73854RNA Polymerase I Promoter Clearance
reactomeR-HSA-73863RNA Polymerase I Transcription Termination
reactomeR-HSA-73864RNA Polymerase I Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
wikipathwaysWP2858Ectoderm Differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBTF

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