UCP2


Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
uncoupling protein 2MIM:601693Ensembl:ENSG00000175567HGNC:HGNC:12518PA3716511q13.4

GO terms in UCP2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000303response to superoxide
BPIDAGO:0001666response to hypoxia
BPIEAGO:0007565female pregnancy
BPIEAGO:0007568aging
BPIBAGO:0009409response to cold
BPIEAGO:0010942positive regulation of cell death
BPIEAGO:0032869cellular response to insulin stimulus
BPIEAGO:0034198cellular response to amino acid starvation
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0051881regulation of mitochondrial membrane potential
BPIEAGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulus
BPIEAGO:0070542response to fatty acid
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0097421liver regeneration
BPTASGO:1902600proton transmembrane transport
BPIBAGO:1990542mitochondrial transmembrane transport
BPIBAGO:1990845adaptive thermogenesis
CCIDAGO:0005739mitochondrion
CCTASGO:0005743mitochondrial inner membrane
MFIPIGO:0005515protein binding
MFIBAGO:0017077oxidative phosphorylation uncoupler activity

Gene expression in normal tissue: UCP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UCP2


DatabasePathway IDPathway Des.
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
reactomeR-HSA-166187Mitochondrial Uncoupling Proteins
reactomeR-HSA-167826The fatty acid cycling model
reactomeR-HSA-167827The proton buffering model
pidhnf3bpathwayFOXA2 and FOXA3 transcription factor networks
wikipathwaysWP111Electron Transport Chain
wikipathwaysWP1541Energy Metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UCP2

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