UCP3


Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
uncoupling protein 3MIM:602044Ensembl:ENSG00000175564HGNC:HGNC:12519PA3716611q13.4

GO terms in UCP3


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005215transporter activity
MFIPIGO:0005515protein binding
MFIBAGO:0017077oxidative phosphorylation uncoupler activity
BPIEAGO:0000303response to superoxide
BPIEAGO:0001666response to hypoxia
BPTASGO:0006629lipid metabolic process
BPIEAGO:0006631fatty acid metabolic process
BPIEAGO:0007568aging
BPIEAGO:0007584response to nutrient
BPTASGO:0007585respiratory gaseous exchange
BPIBAGO:0009409response to cold
BPIEAGO:0014823response to activity
BPIEAGO:0032868response to insulin
BPIEAGO:0032870cellular response to hormone stimulus
BPIEAGO:0051384response to glucocorticoid
BPTASGO:1902600proton transmembrane transport
BPIBAGO:1990542mitochondrial transmembrane transport
BPIBAGO:1990845adaptive thermogenesis
CCTASGO:0005739mitochondrion
CCTASGO:0005743mitochondrial inner membrane

Gene expression in normal tissue: UCP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UCP3


DatabasePathway IDPathway Des.
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
reactomeR-HSA-166187Mitochondrial Uncoupling Proteins
reactomeR-HSA-167826The fatty acid cycling model
reactomeR-HSA-167827The proton buffering model
wikipathwaysWP111Electron Transport Chain
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP410Exercise-induced Circadian Regulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UCP3

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