UCP3
Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
uncoupling protein 3 | MIM:602044 | Ensembl:ENSG00000175564 | HGNC:HGNC:12519 | PA37166 | 11q13.4 |
GO terms in UCP3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0005215 | transporter activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0017077 | oxidative phosphorylation uncoupler activity |
BP | IEA | GO:0000303 | response to superoxide |
BP | IEA | GO:0001666 | response to hypoxia |
BP | TAS | GO:0006629 | lipid metabolic process |
BP | IEA | GO:0006631 | fatty acid metabolic process |
BP | IEA | GO:0007568 | aging |
BP | IEA | GO:0007584 | response to nutrient |
BP | TAS | GO:0007585 | respiratory gaseous exchange |
BP | IBA | GO:0009409 | response to cold |
BP | IEA | GO:0014823 | response to activity |
BP | IEA | GO:0032868 | response to insulin |
BP | IEA | GO:0032870 | cellular response to hormone stimulus |
BP | IEA | GO:0051384 | response to glucocorticoid |
BP | TAS | GO:1902600 | proton transmembrane transport |
BP | IBA | GO:1990542 | mitochondrial transmembrane transport |
BP | IBA | GO:1990845 | adaptive thermogenesis |
CC | TAS | GO:0005739 | mitochondrion |
CC | TAS | GO:0005743 | mitochondrial inner membrane |
Gene expression in normal tissue: UCP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UCP3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
reactome | R-HSA-166187 | Mitochondrial Uncoupling Proteins |
reactome | R-HSA-167826 | The fatty acid cycling model |
reactome | R-HSA-167827 | The proton buffering model |
wikipathways | WP111 | Electron Transport Chain |
wikipathways | WP1541 | Energy Metabolism |
wikipathways | WP410 | Exercise-induced Circadian Regulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UCP3