UGDH
Summary: The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| UDP-glucose 6-dehydrogenase | MIM:603370 | Ensembl:ENSG00000109814 | HGNC:HGNC:12525 | PA37170 | 4p14 |
GO terms in UGDH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003979 | UDP-glucose 6-dehydrogenase activity |
| MF | TAS | GO:0009055 | electron transfer activity |
| MF | IEA | GO:0051287 | NAD binding |
| BP | IEA | GO:0001702 | gastrulation with mouth forming second |
| BP | TAS | GO:0006011 | UDP-glucose metabolic process |
| BP | IBA | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | IEA | GO:0006065 | UDP-glucuronate biosynthetic process |
| BP | TAS | GO:0006065 | UDP-glucuronate biosynthetic process |
| BP | IEA | GO:0022900 | electron transport chain |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: UGDH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UGDH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00010 | Nucleotide Sugars Metabolism |
| smpdb | SMP00058 | Starch and Sucrose Metabolism |
| smpdb | SMP00495 | Galactosemia II (GALK) |
| smpdb | SMP00496 | Galactosemia III |
| smpdb | SMP00552 | Glycogen synthetase deficiency |
| smpdb | SMP00553 | Glycogenosis, Type III. Cori disease, Debrancher glycogenosis |
| smpdb | SMP00554 | Glycogenosis, Type IV. Amylopectinosis, Anderson disease |
| smpdb | SMP00555 | Glycogenosis, Type VI. Hers disease |
| smpdb | SMP00556 | Mucopolysaccharidosis VI. Sly syndrome |
| smpdb | SMP00557 | Sucrase-isomaltase deficiency |
| wikipathways | WP698 | Glucuronidation |
| humancyc | PWY-4821 | UDP-D-xylose and UDP-D-glucuronate biosynthesis |
| kegg | hsa00040 | Pentose and glucuronate interconversions - Homo sapiens (human) |
| kegg | hsa00053 | Ascorbate and aldarate metabolism - Homo sapiens (human) |
| kegg | hsa00520 | Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156588 | Glucuronidation |
| reactome | R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate |
| reactome | R-HSA-211859 | Biological oxidations |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UGDH
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